Version 5.4
Homo sapiens Gene: MACF1
Summary
InnateDB Gene IDBG-96610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MACF1
Gene Name microtubule-actin crosslinking factor 1
Synonyms ABP620; ACF7; MACF; OFC4
Species Homo sapiens
Ensembl Gene ENSG00000127603
Encoded Proteins
IDBP-96614
microtubule-actin crosslinking factor 1
IDBP-96616
microtubule-actin crosslinking factor 1
IDBP-96618
microtubule-actin crosslinking factor 1
IDBP-96628
microtubule-actin crosslinking factor 1
IDBP-96630
microtubule-actin crosslinking factor 1
IDBP-380691
microtubule-actin crosslinking factor 1
IDBP-380695
microtubule-actin crosslinking factor 1
IDBP-380703
microtubule-actin crosslinking factor 1
IDBP-587925
microtubule-actin crosslinking factor 1
IDBP-600539
microtubule-actin crosslinking factor 1
IDBP-594833
microtubule-actin crosslinking factor 1
IDBP-592574
microtubule-actin crosslinking factor 1
IDBP-601030
microtubule-actin crosslinking factor 1
IDBP-595818
microtubule-actin crosslinking factor 1
IDBP-721716
IDBP-721541
IDBP-809962
microtubule-actin crosslinking factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:39081316-39487177
Strand Forward strand
Band p34.3
Transcripts
ENST00000361689 ENSP00000354573
ENST00000372925 ENSP00000362016
ENST00000372915 ENSP00000362006
ENST00000289893 ENSP00000289893
ENST00000360115 ENSP00000353231
ENST00000446276 ENSP00000391512
ENST00000442046 ENSP00000407776
ENST00000422234 ENSP00000412910
ENST00000484793 ENSP00000434859
ENST00000467673
ENST00000494012 ENSP00000435892
ENST00000480624
ENST00000469366
ENST00000496804 ENSP00000435078
ENST00000485063
ENST00000472385
ENST00000484393
ENST00000476350
ENST00000482035 ENSP00000433104
ENST00000473843
ENST00000469490
ENST00000487656
ENST00000497964
ENST00000462496
ENST00000462103
ENST00000496360
ENST00000497807
ENST00000524432 ENSP00000435070
ENST00000530262 ENSP00000437059
ENST00000528611
ENST00000567887 ENSP00000455823
ENST00000564288 ENSP00000455274
ENST00000602421 ENSP00000473615
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
GO:0044822 poly(A) RNA binding
GO:0051015 actin filament binding
Biological Process
GO:0006200 ATP catabolic process
GO:0007050 cell cycle arrest
GO:0010632 regulation of epithelial cell migration
GO:0016055 Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0032886 regulation of microtubule-based process
GO:0042060 wound healing
GO:0043001 Golgi to plasma membrane protein transport
GO:0051893 regulation of focal adhesion assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028649
View Gene Order
ENSBTAG00000021024
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.472475 Hs.723432
RefSeq NM_012090 NM_015038 XM_005270694 XM_005270695 XM_005270700 XM_006710519 XM_006710526 XM_006710527 XM_006710528 XM_006710529 XM_006710530 XM_006710531 XM_006710532 XM_006710533 XM_006710534 XM_006710535 XM_006710538 XM_006710539
HUGO
OMIM
CCDS CCDS435
HPRD 09750
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca