InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS12

Summary

InnateDB Gene

IDBG-96692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS12

Gene Name

ribosomal protein S12

Synonyms

S12

Species

Homo sapiens

Ensembl Gene

ENSG00000112306

Encoded Proteins

IDBP-96698

ribosomal protein S12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:132814441-132817564

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000230050	ENSP00000230050
ENST00000484616

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.

Experimentally validated
Total	101 [view]
Protein-Protein	101 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process