Version 5.4
Homo sapiens Gene: PABPC4
Summary
InnateDB Gene IDBG-96711.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PABPC4
Gene Name poly(A) binding protein, cytoplasmic 4 (inducible form)
Synonyms APP-1; APP1; iPABP; PABP4
Species Homo sapiens
Ensembl Gene ENSG00000090621
Encoded Proteins
IDBP-96713
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-96715
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-96717
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-96719
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-380826
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-380831
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-380835
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-596170
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-583682
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-602967
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-590047
poly(A) binding protein, cytoplasmic 4 (inducible form)
IDBP-602668
poly(A) binding protein, cytoplasmic 4 (inducible form)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:39560816-39576790
Strand Reverse strand
Band p34.3
Transcripts
ENST00000372862 ENSP00000361953
ENST00000372858 ENSP00000361949
ENST00000372857 ENSP00000361948
ENST00000372856 ENSP00000361947
ENST00000421687 ENSP00000398267
ENST00000437136 ENSP00000408559
ENST00000451091 ENSP00000406675
ENST00000492468
ENST00000468476
ENST00000482028
ENST00000484555
ENST00000477556
ENST00000461578
ENST00000483770
ENST00000470443 ENSP00000436391
ENST00000474378 ENSP00000431383
ENST00000492519
ENST00000513632
ENST00000530186 ENSP00000436407
ENST00000525045
ENST00000527718 ENSP00000436566
ENST00000525669
ENST00000525751
ENST00000529216
ENST00000531243 ENSP00000436698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008143 poly(A) binding
GO:0008266 poly(U) RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
GO:0006412 translation
GO:0007596 blood coagulation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000011257
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.169900 Hs.605424 Hs.655282
RefSeq NM_001135653 NM_001135654 NM_003819 XM_005269266 XM_005275723 XM_005276424
HUGO
OMIM
CCDS CCDS438 CCDS44114 CCDS44115
HPRD 04557
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca