Version 5.4
Homo sapiens Gene: PPIE
Summary
InnateDB Gene IDBG-96746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPIE
Gene Name peptidylprolyl isomerase E (cyclophilin E)
Synonyms CYP-33; CYP33
Species Homo sapiens
Ensembl Gene ENSG00000084072
Encoded Proteins
IDBP-96748
peptidylprolyl isomerase E (cyclophilin E)
IDBP-96750
peptidylprolyl isomerase E (cyclophilin E)
IDBP-96754
peptidylprolyl isomerase E (cyclophilin E)
IDBP-96756
peptidylprolyl isomerase E (cyclophilin E)
IDBP-599241
peptidylprolyl isomerase E (cyclophilin E)
IDBP-583148
peptidylprolyl isomerase E (cyclophilin E)
IDBP-600506
peptidylprolyl isomerase E (cyclophilin E)
IDBP-591374
peptidylprolyl isomerase E (cyclophilin E)
IDBP-596878
peptidylprolyl isomerase E (cyclophilin E)
IDBP-585786
peptidylprolyl isomerase E (cyclophilin E)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:39692182-39763914
Strand Forward strand
Band p34.2
Transcripts
ENST00000356511 ENSP00000348904
ENST00000372835 ENSP00000361925
ENST00000324379 ENSP00000312769
ENST00000372830 ENSP00000361918
ENST00000456578
ENST00000470018 ENSP00000436689
ENST00000485507
ENST00000495526 ENSP00000434989
ENST00000482751
ENST00000497370 ENSP00000433475
ENST00000470213 ENSP00000431714
ENST00000474804 ENSP00000432396
ENST00000475350 ENSP00000434888
ENST00000480169
ENST00000467741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0016018 cyclosporin A binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005634 nucleus
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028651
View Gene Order
ENSBTAG00000047314
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PIB0
UniProt Splice Variant
Entrez Gene 10450
UniGene Hs.524690 Hs.715927
RefSeq NM_001195007 NM_006112 NM_203456 XM_006710288 XM_006710290 XM_006710292
HUGO HGNC:9258
OMIM 602435
CCDS CCDS442 CCDS443 CCDS53299
HPRD 03893
IMGT
EMBL AL033527 AL035404 AL049824
GenPept
RNA Seq Atlas 10450

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca