Version 5.4
Homo sapiens Gene: ZMPSTE24
Summary
InnateDB Gene IDBG-96895.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZMPSTE24
Gene Name zinc metallopeptidase STE24 homolog (S. cerevisiae)
Synonyms FACE-1; FACE1; HGPS; PRO1; STE24; Ste24p
Species Homo sapiens
Ensembl Gene ENSG00000084073
Encoded Proteins
IDBP-96897
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40258107-40294184
Strand Forward strand
Band p34.2
Transcripts
ENST00000372759 ENSP00000361845
ENST00000479131
ENST00000472583
ENST00000474142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 21 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006998 nuclear envelope organization
GO:0030327 prenylated protein catabolic process
GO:0071586 CAAX-box protein processing
Cellular Component
GO:0005637 nuclear inner membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043207
View Gene Order
ENSBTAG00000044178
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt O75844
TrEMBL B3KNM6
UniProt Splice Variant
Entrez Gene 10269
UniGene Hs.132642 Hs.618208
RefSeq NM_005857
HUGO HGNC:12877
OMIM 606480
CCDS CCDS449
HPRD 07349
IMGT
EMBL AB016068 AF064867 AK027874 AK075007 AL050341 BC037283 CH471059 Y13834
GenPept AAC68866 AAH37283 BAA33727 BAG51388 BAG52049 CAB46277 CAB81610 EAX07233 EAX07234
RNA Seq Atlas 10269

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca