Version 5.4
Homo sapiens Gene: IFNGR1
Summary
InnateDB Gene IDBG-97020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNGR1
Gene Name interferon gamma receptor 1
Synonyms CD119; IFNGR; IMD27A; IMD27B
Species Homo sapiens
Ensembl Gene ENSG00000027697
Encoded Proteins
IDBP-97022
interferon gamma receptor 1
IDBP-387490
interferon gamma receptor 1
IDBP-387491
interferon gamma receptor 1
IDBP-595511
interferon gamma receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16785527
IFNGR1, along with IFNGR2, are the receptor subunits for IFN-gamma that upon ligand binding, translocate to the nucleus together with STAT1-alpha, and associate with IFN-gamma-activated sequence (GAS) elements at the promoter sites of IFN-gamma-activated genes.
InnateDB Annotation from Orthologs
Summary
PMID 27220602
[Mus musculus] Expression of Cxcl13, Ifngr1, Retnla and Mrc1 distinguishes between large and small resident peritoneal macrophage subsets.
Entrez Gene
Summary This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:137197484-137219449
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367739 ENSP00000356713
ENST00000458076 ENSP00000389249
ENST00000414770 ENSP00000394230
ENST00000478333
ENST00000543628 ENSP00000443282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 19 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004906 interferon-gamma receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
Biological Process
GO:0007165 signal transduction
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030425 dendrite
GO:0031982 vesicle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020009
View Gene Order
Pathways
NETPATH
REACTOME
REACT_24980
Regulation of IFNG signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IFN gamma signaling pathway
PID NCI
shp2_pathway
SHP2 signaling
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL B4DFT7 Q5TFD1
UniProt Splice Variant
Entrez Gene 3459
UniGene
RefSeq NM_000416 XM_006715470 XM_006715471
HUGO HGNC:5439
OMIM 107470
CCDS CCDS5185
HPRD 00127
IMGT
EMBL AK294252 AL050337
GenPept BAG57548
RNA Seq Atlas 3459

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca