InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YBX1

Summary

InnateDB Gene

IDBG-97231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YBX1

Gene Name

Y box binding protein 1

Synonyms

BP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1

Species

Homo sapiens

Ensembl Gene

ENSG00000065978

Encoded Proteins

IDBP-97233

Y box binding protein 1

IDBP-381746

Y box binding protein 1

IDBP-381751

Y box binding protein 1

IDBP-806674

Y box binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25398005

[Mus musculus] Ybx1 controls intracellular Il6 mRNA levels in a cell type-specific manner, leading to functions that are dependent on the extracellular and intracellular distribution of Ybx1.

PMID 26026270

[Mus musculus] Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:42682395-42702349

Strand

Forward strand

Band

p34.2

Transcripts

ENST00000321358	ENSP00000361626
ENST00000332220	ENSP00000405937
ENST00000436427	ENSP00000389639
ENST00000467957
ENST00000616651	ENSP00000484416

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 195 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	195 [view]
Protein-Protein	193 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000398	mRNA splicing, via spliceosome
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0051154	negative regulation of striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005689	U12-type spliceosomal complex
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0030529	ribonucleoprotein complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0070937	CRD-mediated mRNA stability complex
GO:0071204	histone pre-mRNA 3'end processing complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028639

View Gene Order

ENSBTAG00000017368

Not yet available

Pathways

NETPATH

NetPath_14

IL2 pathway

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

ptp1bpathway

Signaling events mediated by PTP1B

Cross-References

SwissProt

P67809

TrEMBL

A0JLU4

UniProt Splice Variant

Entrez Gene

4904

UniGene

Hs.713229

RefSeq

NM_004559

HUGO

HGNC:8014

OMIM

154030

CCDS

CCDS470

HPRD

01095

IMGT

EMBL

BC002411 BC010430 BC015208 BC020164 BC038384 BC065571 BC070084 BC071708 BC090038 BC098435 BC106045 J03827 L28809 M24070 M83234

GenPept

AAA20871 AAA35750 AAA59949 AAA61308 AAH02411 AAH10430 AAH15208 AAH20164 AAH38384 AAH65571 AAH70084 AAH71708 AAH90038 AAH98435 AAI06046

RNA Seq Atlas

4904