Version 5.4
Homo sapiens Gene: TIE1
Summary
InnateDB Gene IDBG-97374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIE1
Gene Name tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms JTK14; TIE
Species Homo sapiens
Ensembl Gene ENSG00000066056
Encoded Proteins
IDBP-97376
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
IDBP-603654
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43300993-43323108
Strand Forward strand
Band p34.2
Transcripts
ENST00000372476 ENSP00000361554
ENST00000485125
ENST00000480269
ENST00000488437
ENST00000471187
ENST00000461061
ENST00000473014
ENST00000492599
ENST00000492874
ENST00000538015 ENSP00000440063
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007498 mesoderm development
GO:0016525 negative regulation of angiogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030336 negative regulation of cell migration
GO:0032526 response to retinoic acid
GO:0045026 plasma membrane fusion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033191
View Gene Order
ENSBTAG00000003777
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.78824
RefSeq NM_001253357 NM_005424 XM_006710869
HUGO
OMIM
CCDS CCDS482
HPRD 02572
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca