InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MPL

Summary

InnateDB Gene

IDBG-97403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPL

Gene Name

myeloproliferative leukemia virus oncogene

Synonyms

C-MPL; CD110; MPLV; THCYT2; TPOR

Species

Homo sapiens

Ensembl Gene

ENSG00000117400

Encoded Proteins

IDBP-97405

myeloproliferative leukemia virus oncogene

IDBP-381938

myeloproliferative leukemia virus oncogene

IDBP-807727

MPL proto-oncogene, thrombopoietin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:43337807-43352772

Strand

Forward strand

Band

p34.2

Transcripts

ENST00000372470	ENSP00000361548
ENST00000413998	ENSP00000414004
ENST00000612993	ENSP00000480273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030168	platelet activation
GO:0032642	regulation of chemokine production
GO:0048872	homeostasis of number of cells

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000006389

View Gene Order

ENSBTAG00000003781

Not yet available

Pathways

NETPATH

REACTOME

REACT_278

Platelet Aggregation (Plug Formation) pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_604

Hemostasis pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

INOH website

TPO signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.82906

RefSeq

NM_005373

HUGO

OMIM

CCDS

CCDS483

HPRD

01161

IMGT

EMBL

GenPept

RNA Seq Atlas