Version 5.4
Homo sapiens Gene: SZT2
Summary
InnateDB Gene IDBG-97454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SZT2
Gene Name seizure threshold 2 homolog (mouse)
Synonyms C1orf84; EIEE18; KIAA0467; SZT2A; SZT2B
Species Homo sapiens
Ensembl Gene ENSG00000198198
Encoded Proteins
IDBP-97456
Protein SZT2
IDBP-292982
Protein SZT2
IDBP-722213
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43389882-43452650
Strand Forward strand
Band p34.2
Transcripts
ENST00000372450 ENSP00000361528
ENST00000357658
ENST00000406439 ENSP00000386070
ENST00000470139
ENST00000478140
ENST00000470897
ENST00000471177
ENST00000460536
ENST00000562955 ENSP00000457168
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007417 central nervous system development
GO:0009790 embryo development
GO:0009791 post-embryonic development
GO:0021540 corpus callosum morphogenesis
GO:0043473 pigmentation
GO:1901668 regulation of superoxide dismutase activity
Cellular Component
GO:0005777 peroxisome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033253
View Gene Order
ENSBTAG00000005580
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643560
RefSeq NM_015284
HUGO
OMIM
CCDS CCDS30694
HPRD 11085
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca