Version 5.4
Homo sapiens Gene: DPH2
Summary
InnateDB Gene IDBG-97615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH2
Gene Name DPH2 homolog (S. cerevisiae)
Synonyms DPH2L2
Species Homo sapiens
Ensembl Gene ENSG00000132768
Encoded Proteins
IDBP-97617
DPH2 homolog (S. cerevisiae)
IDBP-236837
DPH2 homolog (S. cerevisiae)
IDBP-600147
DPH2 homolog (S. cerevisiae)
IDBP-594308
DPH2 homolog (S. cerevisiae)
IDBP-585538
DPH2 homolog (S. cerevisiae)
IDBP-599966
DPH2 homolog (S. cerevisiae)
IDBP-589016
DPH2 homolog (S. cerevisiae)
IDBP-584865
DPH2 homolog (S. cerevisiae)
IDBP-602109
DPH2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43970000-43973369
Strand Forward strand
Band p34.1
Transcripts
ENST00000255108 ENSP00000255108
ENST00000396758 ENSP00000379981
ENST00000471934
ENST00000476260 ENSP00000436330
ENST00000495421 ENSP00000431944
ENST00000492306 ENSP00000433273
ENST00000490861
ENST00000477294
ENST00000459879 ENSP00000432162
ENST00000524776 ENSP00000434977
ENST00000530988
ENST00000527567
ENST00000529729
ENST00000532140 ENSP00000431831
ENST00000534786
ENST00000534655
ENST00000527319 ENSP00000435561
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028540
View Gene Order
ENSBTAG00000018888
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632398
RefSeq NM_001039589 NM_001384 XM_005270559
HUGO
OMIM
CCDS CCDS41314 CCDS504
HPRD 16023
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca