Version 5.4
Homo sapiens Gene: STXBP5
Summary
InnateDB Gene IDBG-97618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STXBP5
Gene Name syntaxin binding protein 5 (tomosyn)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164506
Encoded Proteins
IDBP-97620
syntaxin binding protein 5 (tomosyn)
IDBP-97622
syntaxin binding protein 5 (tomosyn)
IDBP-97626
syntaxin binding protein 5 (tomosyn)
IDBP-97632
syntaxin binding protein 5 (tomosyn)
IDBP-245949
syntaxin binding protein 5 (tomosyn)
IDBP-587828
syntaxin binding protein 5 (tomosyn)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:147204425-147385730
Strand Forward strand
Band q24.3
Transcripts
ENST00000367481 ENSP00000356451
ENST00000367480 ENSP00000356450
ENST00000321680 ENSP00000321826
ENST00000367475 ENSP00000356445
ENST00000392291 ENSP00000376112
ENST00000546097 ENSP00000441479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
Biological Process
GO:0006887 exocytosis
GO:0010468 regulation of gene expression
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0017157 regulation of exocytosis
GO:0030193 regulation of blood coagulation
GO:0045921 positive regulation of exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005892 acetylcholine-gated channel complex
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019790
View Gene Order
ENSBTAG00000021107
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 134957
UniGene Hs.86320
RefSeq NM_001127715 NM_139244
HUGO HGNC:19665
OMIM 604586
CCDS CCDS47499 CCDS5211
HPRD 06845
IMGT
EMBL
GenPept
RNA Seq Atlas 134957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca