Version 5.4
Homo sapiens Gene: LATS1
Summary
InnateDB Gene IDBG-97771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LATS1
Gene Name LATS, large tumor suppressor, homolog 1 (Drosophila)
Synonyms WARTS; wts
Species Homo sapiens
Ensembl Gene ENSG00000131023
Encoded Proteins
IDBP-97773
LATS, large tumor suppressor, homolog 1 (Drosophila)
IDBP-591516
LATS, large tumor suppressor, homolog 1 (Drosophila)
IDBP-387744
LATS, large tumor suppressor, homolog 1 (Drosophila)
IDBP-597317
LATS, large tumor suppressor, homolog 1 (Drosophila)
IDBP-600043
LATS, large tumor suppressor, homolog 1 (Drosophila)
IDBP-590583
LATS, large tumor suppressor, homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:149658153-149718256
Strand Reverse strand
Band q25.1
Transcripts
ENST00000253339 ENSP00000253339
ENST00000392273 ENSP00000444678
ENST00000441107 ENSP00000403815
ENST00000458696 ENSP00000441265
ENST00000543571 ENSP00000437550
ENST00000542747
ENST00000542720 ENSP00000444535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 121 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000819 sister chromatid segregation
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0009755 hormone-mediated signaling pathway
GO:0030216 keratinocyte differentiation
GO:0030833 regulation of actin filament polymerization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035329 hippo signaling
GO:0043254 regulation of protein complex assembly
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051220 cytoplasmic sequestering of protein
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005815 microtubule organizing center
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040021
View Gene Order
ENSBTAG00000015076
Not yet available
Pathways
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.549084 Hs.633030
RefSeq NM_001270519 NM_004690 XM_006715603
HUGO
OMIM
CCDS CCDS34551 CCDS59040
HPRD 09147
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca