InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LZTS1

Summary

InnateDB Gene

IDBG-9778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LZTS1

Gene Name

leucine zipper, putative tumor suppressor 1

Synonyms

F37; FEZ1

Species

Homo sapiens

Ensembl Gene

ENSG00000061337

Encoded Proteins

IDBP-9780

leucine zipper, putative tumor suppressor 1

IDBP-9786

leucine zipper, putative tumor suppressor 1

IDBP-474472

leucine zipper, putative tumor suppressor 1

IDBP-810144

leucine zipper, putative tumor suppressor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:20246165-20303963

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000381569	ENSP00000370981
ENST00000265801	ENSP00000265801
ENST00000522290	ENSP00000429263
ENST00000616228	ENSP00000479534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0007049	cell cycle
GO:0010467	gene expression
GO:0016242	negative regulation of macroautophagy
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0044297	cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036306

View Gene Order

ENSBTAG00000000841

Not yet available

Cross-References

SwissProt

Q9Y250

TrEMBL

UniProt Splice Variant

Entrez Gene

11178

UniGene

Hs.521432

RefSeq

NM_021020 XM_005273394

HUGO

HGNC:13861

OMIM

606551

CCDS

CCDS6015

HPRD

IMGT

EMBL

AF123652 AF123653 AF123654 AF123655 AF123656 AF123657 AF123658 AF123659 BC075006 BC075007 CH471080

GenPept

AAD23833 AAD23834 AAD23835 AAD23836 AAD23837 AAD23838 AAD23839 AAD23840 AAH75006 AAH75007 EAW63753 EAW63755

RNA Seq Atlas

11178