Version 5.4
Homo sapiens Gene: AKAP12
Summary
InnateDB Gene IDBG-97940.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP12
Gene Name A kinase (PRKA) anchor protein 12
Synonyms AKAP250; SSeCKS
Species Homo sapiens
Ensembl Gene ENSG00000131016
Encoded Proteins
IDBP-97942
A kinase (PRKA) anchor protein 12
IDBP-97944
A kinase (PRKA) anchor protein 12
IDBP-97946
A kinase (PRKA) anchor protein 12
IDBP-293119
A kinase (PRKA) anchor protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:151239999-151358557
Strand Forward strand
Band q25.1
Transcripts
ENST00000253332 ENSP00000253332
ENST00000359755 ENSP00000352794
ENST00000354675 ENSP00000346702
ENST00000402676 ENSP00000384537
ENST00000490177
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010739 positive regulation of protein kinase A signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0090036 regulation of protein kinase C signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005938 cell cortex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038587
View Gene Order
ENSBTAG00000014788
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371240 Hs.602577 Hs.711689
RefSeq NM_005100 NM_144497 XM_005267233 XM_005267234 XM_005267235
HUGO
OMIM
CCDS CCDS5229 CCDS5230
HPRD 05263
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca