InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ESR1

Summary

InnateDB Gene

IDBG-97997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESR1

Gene Name

estrogen receptor 1

Synonyms

ER; Era; ESR; ESRA; ESTRR; NR3A1

Species

Homo sapiens

Ensembl Gene

ENSG00000091831

Encoded Proteins

IDBP-97999

estrogen receptor 1

IDBP-98001

estrogen receptor 1

IDBP-293110

estrogen receptor 1

IDBP-293116

estrogen receptor 1

IDBP-387826

estrogen receptor 1

IDBP-387827

estrogen receptor 1

IDBP-387828

estrogen receptor 1

IDBP-387833

estrogen receptor 1

IDBP-387835

estrogen receptor 1

IDBP-387836

estrogen receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:151656691-152129619

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000206249	ENSP00000206249
ENST00000338799	ENSP00000342630
ENST00000406599	ENSP00000384064
ENST00000404742	ENSP00000385373
ENST00000440973	ENSP00000405330
ENST00000446550	ENSP00000411105
ENST00000443427	ENSP00000387500
ENST00000456483	ENSP00000415934
ENST00000427531	ENSP00000394721
ENST00000415488	ENSP00000401995
ENST00000473497
ENST00000488573
ENST00000482101

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 764 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	764 [view]
Protein-Protein	728 [view]
Protein-DNA	27 [view]
Protein-RNA	1 [view]
DNA-DNA	8 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0030284	estrogen receptor activity
GO:0034056	estrogen response element binding
GO:0038052	estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001547	antral ovarian follicle growth
GO:0002064	epithelial cell development
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008209	androgen metabolic process
GO:0008584	male gonad development
GO:0010467	gene expression
GO:0010629	negative regulation of gene expression
GO:0010863	positive regulation of phospholipase C activity
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0032355	response to estradiol
GO:0042981	regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401	steroid hormone mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043627	response to estrogen
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048386	positive regulation of retinoic acid receptor signaling pathway
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060523	prostate epithelial cord elongation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060745	mammary gland branching involved in pregnancy
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane