InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TIAM2

Summary

InnateDB Gene

IDBG-98237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIAM2

Gene Name

T-cell lymphoma invasion and metastasis 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000146426

Encoded Proteins

IDBP-98245

T-cell lymphoma invasion and metastasis 2

IDBP-98247

T-cell lymphoma invasion and metastasis 2

IDBP-98249

T-cell lymphoma invasion and metastasis 2

IDBP-388021

T-cell lymphoma invasion and metastasis 2

IDBP-594665

T-cell lymphoma invasion and metastasis 2

IDBP-594898

T-cell lymphoma invasion and metastasis 2

IDBP-588419

T-cell lymphoma invasion and metastasis 2

IDBP-595128

T-cell lymphoma invasion and metastasis 2

IDBP-586112

T-cell lymphoma invasion and metastasis 2

IDBP-596476

T-cell lymphoma invasion and metastasis 2

IDBP-591571

T-cell lymphoma invasion and metastasis 2

IDBP-585357

T-cell lymphoma invasion and metastasis 2

IDBP-603004

T-cell lymphoma invasion and metastasis 2

IDBP-586334

T-cell lymphoma invasion and metastasis 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:154832697-155257723

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000318981	ENSP00000327315
ENST00000360366	ENSP00000353528
ENST00000275246	ENSP00000275246
ENST00000431620
ENST00000449545
ENST00000456877	ENSP00000407183
ENST00000460692
ENST00000461783	ENSP00000437188
ENST00000462408	ENSP00000431269
ENST00000535064
ENST00000545347	ENSP00000444040
ENST00000538270	ENSP00000437435
ENST00000535231	ENSP00000443546
ENST00000528535	ENSP00000434901
ENST00000535583	ENSP00000442989
ENST00000529824	ENSP00000433348
ENST00000528391	ENSP00000435335
ENST00000543712	ENSP00000444897
ENST00000539296
ENST00000546145
ENST00000537845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030426	growth cone
GO:0070062	extracellular vesicular exosome