InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CMPK1

Summary

InnateDB Gene

IDBG-98280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CMPK1

Gene Name

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000162368

Encoded Proteins

IDBP-98284

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

IDBP-98286

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

IDBP-383736

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

IDBP-592431

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:47333797-47378839

Strand

Forward strand

Band

p33

Transcripts

ENST00000371873	ENSP00000360939
ENST00000371871	ENSP00000360937
ENST00000371870
ENST00000450808	ENSP00000398192
ENST00000471289	ENSP00000433782

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004127	cytidylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0004849	uridine kinase activity
GO:0005524	ATP binding
GO:0009041	uridylate kinase activity
GO:0016301	kinase activity
GO:0019205	nucleobase-containing compound kinase activity
GO:0033862	UMP kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006222	UMP biosynthetic process
GO:0006225	UDP biosynthetic process
GO:0006227	dUDP biosynthetic process
GO:0006240	dCDP biosynthetic process
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0009220	pyrimidine ribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0016310	phosphorylation
GO:0018963	phthalate metabolic process
GO:0022602	ovulation cycle process
GO:0044281	small molecule metabolic process
GO:0046705	CDP biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028719

View Gene Order

ENSBTAG00000019956

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.731647

RefSeq

NM_001136140 NM_016308

HUGO

OMIM

CCDS

CCDS44135 CCDS549

HPRD

18258

IMGT

EMBL

GenPept

RNA Seq Atlas