InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPY

Summary

InnateDB Gene

IDBG-9837.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPY

Gene Name

neuropeptide Y

Synonyms

PYY4

Species

Homo sapiens

Ensembl Gene

ENSG00000122585

Encoded Proteins

IDBP-9839

neuropeptide Y

IDBP-294802

neuropeptide Y

IDBP-294806

neuropeptide Y

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:24284163-24291865

Strand

Forward strand

Band

p15.3

Transcripts

ENST00000242152	ENSP00000242152
ENST00000407573	ENSP00000384364
ENST00000405982	ENSP00000385282

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005246	calcium channel regulator activity

Biological Process

GO:0006816	calcium ion transport
GO:0006928	cellular component movement
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007586	digestion
GO:0007610	behavior
GO:0007631	feeding behavior
GO:0008015	blood circulation
GO:0008217	regulation of blood pressure
GO:0008283	cell proliferation
GO:0008343	adult feeding behavior
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0031175	neuron projection development
GO:0032100	positive regulation of appetite

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005623	cell

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029819

View Gene Order

ENSBTAG00000004503

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04920

Adipocytokine signaling pathway pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000905

HUGO

OMIM

CCDS

CCDS5387

HPRD

01214

IMGT

EMBL

GenPept

RNA Seq Atlas