InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNX9

Summary

InnateDB Gene

IDBG-98390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX9

Gene Name

sorting nexin 9

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000130340

Encoded Proteins

IDBP-246173

sorting nexin 9

IDBP-811109

sorting nexin 9

IDBP-811110

sorting nexin 9

IDBP-811132

sorting nexin 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:157700387-157945077

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000392185	ENSP00000376024
ENST00000614703	ENSP00000482920
ENST00000614800	ENSP00000479382
ENST00000611124	ENSP00000482087

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	46 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding
GO:0031625	ubiquitin protein ligase binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0032461	positive regulation of protein oligomerization
GO:0036089	cleavage furrow formation
GO:0043547	positive regulation of GTPase activity
GO:0060988	lipid tube assembly

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030136	clathrin-coated vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002365

View Gene Order

ENSBTAG00000006323

Not yet available

Pathways

NETPATH

REACTOME

REACT_19400

Golgi Associated Vesicle Biogenesis pathway

REACT_19187

Clathrin derived vesicle budding pathway

REACT_11235

trans-Golgi Network Vesicle Budding pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B3KXH8

UniProt Splice Variant

Entrez Gene

51429

UniGene

RefSeq

XM_005267015 NM_016224

HUGO

HGNC:14973

OMIM

605952

CCDS

CCDS5253

HPRD

IMGT

EMBL

AK127345

GenPept

BAG54490

RNA Seq Atlas

51429