InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPS15

Summary

InnateDB Gene

IDBG-98484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPS15

Gene Name

epidermal growth factor receptor pathway substrate 15

Synonyms

AF-1P; AF1P; MLLT5

Species

Homo sapiens

Ensembl Gene

ENSG00000085832

Encoded Proteins

IDBP-98486

epidermal growth factor receptor pathway substrate 15

IDBP-98488

epidermal growth factor receptor pathway substrate 15

IDBP-809715

epidermal growth factor receptor pathway substrate 15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:51354263-51519328

Strand

Reverse strand

Band

p32.3

Transcripts

ENST00000371733	ENSP00000360798
ENST00000371730	ENSP00000360795
ENST00000371727
ENST00000486505
ENST00000478657
ENST00000493793
ENST00000464478
ENST00000471391
ENST00000465467	ENSP00000474739

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	151 [view]
Protein-Protein	150 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0031593	polyubiquitin binding
GO:0042802	identical protein binding

Biological Process

GO:0006895	Golgi to endosome transport
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0016050	vesicle organization
GO:0032456	endocytic recycling
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030122	AP-2 adaptor complex
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane