InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF2S1

Summary

InnateDB Gene

IDBG-9859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2S1

Gene Name

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Synonyms

EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A

Species

Homo sapiens

Ensembl Gene

ENSG00000134001

Encoded Proteins

IDBP-9861

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

IDBP-478315

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

IDBP-586107

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

IDBP-594473

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:67359997-67386516

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000256383	ENSP00000256383
ENST00000466499	ENSP00000425299
ENST00000556724
ENST00000557310	ENSP00000451975
ENST00000555876	ENSP00000452034
ENST00000554332

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	59 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0010467	gene expression
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0043558	regulation of translational initiation in response to stress
GO:0044267	cellular protein metabolic process
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005844	polysome
GO:0005850	eukaryotic translation initiation factor 2 complex
GO:0005851	eukaryotic translation initiation factor 2B complex
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome