Homo sapiens Gene: ORC1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-98628.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ORC1 | ||||||||||||||||||||||
Gene Name | origin recognition complex, subunit 1 | ||||||||||||||||||||||
Synonyms | HSORC1; ORC1L; PARC1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000085840 | ||||||||||||||||||||||
Encoded Proteins |
origin recognition complex, subunit 1
origin recognition complex, subunit 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:52372829-52404459 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p32.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Activation of ATR in response to replication stress pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Association of licensing factors with the pre-replicative complex pathway
Switching of origins to a post-replicative state pathway
Activation of the pre-replicative complex pathway
CDC6 association with the ORC:origin complex pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the ORC complex at the origin of replication pathway
Assembly of the pre-replicative complex pathway
G1/S-Specific Transcription pathway
E2F-enabled inhibition of pre-replication complex formation pathway
E2F mediated regulation of DNA replication pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Regulation of DNA replication pathway
Cell Cycle Checkpoints pathway
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KEGG |
Cell cycle pathway
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INOH | |||||||||||||||||||||||
PID NCI |
E2F transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.17908 | ||||||||||||||||||||||
RefSeq | NM_001190818 NM_001190819 NM_004153 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS566 | ||||||||||||||||||||||
HPRD | 03544 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||