InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC22A3

Summary

InnateDB Gene

IDBG-98707.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A3

Gene Name

solute carrier family 22 (extraneuronal monoamine transporter), member 3

Synonyms

EMT; EMTH; OCT3

Species

Homo sapiens

Ensembl Gene

ENSG00000146477

Encoded Proteins

IDBP-98709

solute carrier family 22 (extraneuronal monoamine transporter), member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25561729

SLC22A3 deficiency significantly decreases lipopolysaccharide- induced monocytic inflammatory response by interrupting NF-kB and MAPKs (mitogen-activated protein kinases) signalling cascades in a histamine dependent manner.

Entrez Gene

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:160348268-160452581

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000275300

ENSP00000275300

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005329	dopamine transmembrane transporter activity
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0019534	toxin transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006855	drug transmembrane transport
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0032098	regulation of appetite
GO:0034220	ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051608	histamine transport
GO:0051615	histamine uptake
GO:0055085	transmembrane transport
GO:1901998	toxin transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023828

View Gene Order

ENSBTAG00000039080

Not yet available

Pathways

NETPATH

REACTOME

REACT_22357

Organic cation transport pathway

REACT_19305

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway

REACT_120801

Abacavir transmembrane transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_22345

Organic cation/anion/zwitterion transport pathway

REACT_121189

Abacavir transport and metabolism pathway

REACT_111217

Metabolism pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O75751

TrEMBL

Q96KH7 Q9NQC0

UniProt Splice Variant

Entrez Gene

6581

UniGene

Hs.606278 Hs.742534

RefSeq

NM_021977 XM_005267106

HUGO

HGNC:10967

OMIM

604842

CCDS

CCDS5277

HPRD

IMGT

EMBL

AF078749 AJ001417 AJ251884 AJ403946 AJ403947 AJ403948 AJ403949 AJ403950 AJ403951 AJ403952 AJ403953 AK314590 AL355506 AL591069 CH471051

GenPept

AAD20977 BAG37164 CAA04751 CAB96132 CAC39443 CAI16539 CAI20340 EAW47599

RNA Seq Atlas

6581