InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAGOH

Summary

InnateDB Gene

IDBG-98726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGOH

Gene Name

mago-nashi homolog, proliferation-associated (Drosophila)

Synonyms

MAGOH1; MAGOHA

Species

Homo sapiens

Ensembl Gene

ENSG00000162385

Encoded Proteins

IDBP-98728

mago-nashi homolog, proliferation-associated (Drosophila)

IDBP-98730

mago-nashi homolog, proliferation-associated (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:53226892-53238610

Strand

Reverse strand

Band

p32.3

Transcripts

ENST00000371470	ENSP00000360525
ENST00000371466	ENSP00000360521
ENST00000495868
ENST00000462941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 202 experimentally validated interaction(s) in this database.

Experimentally validated
Total	202 [view]
Protein-Protein	198 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0006417	regulation of translation
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031124	mRNA 3'-end processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0071013	catalytic step 2 spliceosome