InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LRP8

Summary

InnateDB Gene

IDBG-98740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRP8

Gene Name

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Synonyms

APOER2; HSZ75190; LRP-8; MCI1

Species

Homo sapiens

Ensembl Gene

ENSG00000157193

Encoded Proteins

IDBP-98742

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-98744

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-98746

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-98748

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-591950

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-598502

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-590428

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-587275

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-602630

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

IDBP-806533

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:53245539-53328070

Strand

Reverse strand

Band

p32.3

Transcripts

ENST00000347547	ENSP00000334522
ENST00000306052	ENSP00000303634
ENST00000371454	ENSP00000360509
ENST00000354412	ENSP00000346391
ENST00000465675	ENSP00000437009
ENST00000480045	ENSP00000433554
ENST00000459674
ENST00000460214
ENST00000481431	ENSP00000435346
ENST00000475501	ENSP00000436651
ENST00000496580
ENST00000529670	ENSP00000431241
ENST00000613948	ENSP00000480025

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008035	high-density lipoprotein particle binding
GO:0019894	kinesin binding
GO:0030229	very-low-density lipoprotein particle receptor activity
GO:0034185	apolipoprotein binding
GO:0038025	reelin receptor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001523	retinoid metabolic process
GO:0006508	proteolysis
GO:0006629	lipid metabolic process
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0007603	phototransduction, visible light
GO:0019221	cytokine-mediated signaling pathway
GO:0021541	ammon gyrus development
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021987	cerebral cortex development
GO:0032793	positive regulation of CREB transcription factor activity
GO:0038026	reelin-mediated signaling pathway
GO:0042493	response to drug
GO:0045860	positive regulation of protein kinase activity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804	regulation of synaptic transmission
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0071363	cellular response to growth factor stimulus
GO:0071397	cellular response to cholesterol
GO:1900006	positive regulation of dendrite development

Cellular Component

GO:0005576	extracellular region
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043235	receptor complex