Homo sapiens Gene: DIO1 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-98807.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | DIO1 | ||||||||||
Gene Name | deiodinase, iodothyronine, type I | ||||||||||
Synonyms | 5DI; TXDI1 | ||||||||||
Species | Homo sapiens | ||||||||||
Ensembl Gene | ENSG00000211452 | ||||||||||
Encoded Proteins |
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3\',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 1:53891239-53911086 | ||||||||||
Strand | Forward strand | ||||||||||
Band | p32.3 | ||||||||||
Transcripts | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||
NETPATH | |||||||||||
REACTOME |
Thyroxine biosynthesis pathway
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Regulation of thyroid hormone activity pathway
Metabolism pathway
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KEGG | |||||||||||
INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | Hs.251415 | ||||||||||
RefSeq | NM_000792 NM_001039715 NM_001039716 NM_213593 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | CCDS30722 CCDS41339 CCDS41340 CCDS53320 | ||||||||||
HPRD | 01002 | ||||||||||
IMGT | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||