Homo sapiens Gene: PARK2
Summary
InnateDB Gene IDBG-98830.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PARK2
Gene Name parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Synonyms AR-JP; LPRS2; PDJ; PRKN;
Species Homo sapiens
Ensembl Gene ENSG00000185345
Encoded Proteins
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Protein Structure
InnateDB Annotation
Summary
PARK2 was recently shown to promote the clearance of impaired mitochondria by autophagy, termed mitophagy; PARK2 promotes mitophagy by catalyzing mitochondrial ubiquitination, which in turn recruits ubiquitin-binding autophagy components, HDAC6 and p62, leading to mitochondrial clearance.
PARK2 is important for innate defence against M. tuberculosis for having a role in ubiquitin-mediated autophagy of M. tuberculosis
Entrez Gene
Summary The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:161768452-163148803
Strand Reverse strand
Band q26
Transcripts
ENST00000366898 ENSP00000355865
ENST00000366897 ENSP00000355863
ENST00000366896 ENSP00000355862
ENST00000338468 ENSP00000343589
ENST00000366894 ENSP00000355860
ENST00000366892 ENSP00000355858
ENST00000479615 ENSP00000434414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 195 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 195 [view]
Protein-Protein 192 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein ligase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016881 acid-amino acid ligase activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0051087 chaperone binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0000422 mitochondrion degradation
GO:0001933 negative regulation of protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0007417 central nervous system development
GO:0008219 cell death
GO:0010506 regulation of autophagy
GO:0032232 negative regulation of actin filament bundle assembly
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051865 protein autoubiquitination
GO:0060548 negative regulation of cell death
GO:0070534 protein K63-linked ubiquitination
GO:0070842 aggresome assembly
GO:0070936 protein K48-linked ubiquitination
GO:0070997 neuron death
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016235 aggresome
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
Parkinson`s disease pathway
INOH
PID BIOCARTA
Alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease [Biocarta view]
Role of parkin in ubiquitin-proteasomal pathway [Biocarta view]
PID NCI
Alpha-synuclein signaling
Cross-References
SwissProt O60260
TrEMBL B1AKC3 Q5VVX1 Q5VVX3 Q5VVX4 Q5XNR7 Q6Q2I8 Q6S8G7
UniProt Splice Variant
Entrez Gene 5071
UniGene Hs.132954
RefSeq NM_004562 NM_013987 NM_013988
HUGO 8607
OMIM 602544
CCDS CCDS5281 CCDS5282 CCDS5283
HPRD 03967
IMGT
EMBL AB009973 AF381282 AF381283 AF381286 AK292590 AL008631 AL035697 AL078583 AL132982 AL138716 AL445215 AP000886 AP000887 AP000888 AP001576 AP001577 AP001578 AP002091 AP003699 AY463003 AY564223 AY564225 AY745247 BC022014 CH471051 DQ019286 EF375726 GU345839
GenPept AAH22014 AAM21457 AAM21458 AAM21461 AAR27057 AAS88420 AAS88422 AAU93632 AAY85310 ABN46990 ADB90270 BAA25751 BAF85279 CAH73681 CAH73682 CAH73683 CAH73685 CAI21384 CAI21385 CAI21386 CAI21387 CAI21388 CAI23601 CAI23602 CAI23603 CAI23604 EAW47573 EAW47574
ImmGen PARK2 (murine)
RNA Seq Atlas 5071