Version 5.4
Homo sapiens Gene: PPAP2B
Summary
InnateDB Gene IDBG-99131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAP2B
Gene Name phosphatidic acid phosphatase type 2B
Synonyms Dri42; LPP3; PAP2B; VCIP
Species Homo sapiens
Ensembl Gene ENSG00000162407
Encoded Proteins
IDBP-99135
phosphatidic acid phosphatase type 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:56494747-56645301
Strand Reverse strand
Band p32.2
Transcripts
ENST00000371250 ENSP00000360296
ENST00000472957
ENST00000459962
ENST00000461655
ENST00000476206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008195 phosphatidate phosphatase activity
GO:0042392 sphingosine-1-phosphate phosphatase activity
GO:0042577 lipid phosphatase activity
Biological Process
GO:0001568 blood vessel development
GO:0001702 gastrulation with mouth forming second
GO:0001933 negative regulation of protein phosphorylation
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0007155 cell adhesion
GO:0008354 germ cell migration
GO:0016311 dephosphorylation
GO:0016337 single organismal cell-cell adhesion
GO:0030111 regulation of Wnt signaling pathway
GO:0030148 sphingolipid biosynthetic process
GO:0034109 homotypic cell-cell adhesion
GO:0044281 small molecule metabolic process
GO:0044328 canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration
GO:0044329 canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion
GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060020 Bergmann glial cell differentiation
GO:0060070 canonical Wnt signaling pathway
GO:1902068 regulation of sphingolipid mediated signaling pathway
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028517
View Gene Order
ENSBTAG00000011640
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.405156 Hs.619002 Hs.729767 Hs.730129
RefSeq NM_003713
HUGO
OMIM
CCDS CCDS604
HPRD 06179
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca