Version 5.4
Homo sapiens Gene: THBS2
Summary
InnateDB Gene IDBG-99215.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THBS2
Gene Name thrombospondin 2
Synonyms TSP2
Species Homo sapiens
Ensembl Gene ENSG00000186340
Encoded Proteins
IDBP-99217
thrombospondin 2
IDBP-388328
thrombospondin 2
IDBP-811696
thrombospondin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:169215780-169254044
Strand Reverse strand
Band q27
Transcripts
ENST00000366787 ENSP00000355751
ENST00000435791 ENSP00000398928
ENST00000488355
ENST00000461848
ENST00000472733
ENST00000617924 ENSP00000482784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0007155 cell adhesion
GO:0016525 negative regulation of angiogenesis
GO:0051965 positive regulation of synapse assembly
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023885
View Gene Order
ENSBTAG00000018810
Not yet available
Pathways
NETPATH
REACTOME
REACT_16888
Signaling by PDGF pathway
REACT_22161
Post-translational protein modification pathway
REACT_111102
Signal Transduction pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05144
Malaria pathway
hsa04145
Phagosome pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt P35442
TrEMBL Q5RI53 Q6MZL6
UniProt Splice Variant
Entrez Gene 7058
UniGene Hs.371147 Hs.599698 Hs.604579
RefSeq NM_003247
HUGO HGNC:11786
OMIM 188061
CCDS CCDS34574
HPRD 01766
IMGT
EMBL AK292429 BC146676 BC150175 BX322234 BX641023 CH471051 L12350 M81339
GenPept AAA03703 AAI46677 AAI50176 BAF85118 CAE46014 CAI23645 EAW47455
RNA Seq Atlas 7058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca