InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TBP

Summary

InnateDB Gene

IDBG-99313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBP

Gene Name

TATA box binding protein

Synonyms

GTF2D; GTF2D1; HDL4; SCA17; TFIID

Species

Homo sapiens

Ensembl Gene

ENSG00000112592

Encoded Proteins

IDBP-99315

TATA box binding protein

IDBP-246364

TATA box binding protein

IDBP-388376

TATA box binding protein

IDBP-388377

TATA box binding protein

IDBP-388378

TATA box binding protein

IDBP-593984

TATA box binding protein

IDBP-811460

TATA box binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:170554302-170572870

Strand

Forward strand

Band

q27

Transcripts

ENST00000230354	ENSP00000230354
ENST00000392092	ENSP00000375942
ENST00000421512	ENSP00000400008
ENST00000423353	ENSP00000416482
ENST00000446829	ENSP00000404905
ENST00000540980	ENSP00000442132
ENST00000616883	ENSP00000484118

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	242 [view]
Protein-Protein	226 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006383	transcription from RNA polymerase III promoter
GO:0007283	spermatogenesis
GO:0008219	cell death
GO:0010467	gene expression
GO:0016032	viral process
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0001939	female pronucleus
GO:0001940	male pronucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005672	transcription factor TFIIA complex
GO:0005719	nuclear euchromatin
GO:0005737	cytoplasm
GO:0045120	pronucleus