Version 5.4
Homo sapiens Gene: MIER1
Summary
InnateDB Gene IDBG-99523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIER1
Gene Name mesoderm induction early response 1 homolog (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198160
Encoded Proteins
IDBP-99525
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-99527
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-99531
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-99533
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-99535
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-99537
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-99539
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-226764
mesoderm induction early response 1 homolog (Xenopus laevis)
IDBP-226766
mesoderm induction early response 1 homolog (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). In human, this gene functions as a growth-factor-induced immediate early gene that encodes a transcriptional regulator. Depending on the cellular context, this gene can function as both an activator and repressor of gene transcription. Alternative splicing results in multiple isoforms; some of which contain a nuclear localization signal. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:66924895-66988619
Strand Forward strand
Band p31.3
Transcripts
ENST00000357692 ENSP00000350321
ENST00000371018 ENSP00000360057
ENST00000355977 ENSP00000348253
ENST00000371016 ENSP00000360055
ENST00000371014 ENSP00000360053
ENST00000371012 ENSP00000360051
ENST00000355356 ENSP00000347514
ENST00000401042 ENSP00000383821
ENST00000401041 ENSP00000383820
ENST00000479067
ENST00000493357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0031937 positive regulation of chromatin silencing
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028522
View Gene Order
ENSBTAG00000005443
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601010 Hs.605432 Hs.620351 Hs.709000
RefSeq NM_001077700 NM_001077701 NM_001077702 NM_001077703 NM_001077704 NM_001146110 NM_001146111 NM_001146112 NM_001146113 NM_001278215 NM_020948 XM_005271075 XM_005271076 XM_005271077 XM_006710794
HUGO
OMIM
CCDS CCDS41347 CCDS41348 CCDS53325 CCDS53326 CCDS53327 CCDS53328 CCDS53329 CCDS53330 CCDS60163
HPRD 11362
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca