Version 5.4
Homo sapiens Gene: WLS
Summary
InnateDB Gene IDBG-99591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WLS
Gene Name wntless homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116729
Encoded Proteins
IDBP-99593
wntless homolog (Drosophila)
IDBP-99595
wntless homolog (Drosophila)
IDBP-99597
wntless homolog (Drosophila)
IDBP-99599
wntless homolog (Drosophila)
IDBP-99601
wntless homolog (Drosophila)
IDBP-592160
wntless homolog (Drosophila)
IDBP-592954
wntless homolog (Drosophila)
IDBP-590371
wntless homolog (Drosophila)
IDBP-603843
wntless homolog (Drosophila)
IDBP-595701
wntless homolog (Drosophila)
IDBP-593738
wntless homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:68098473-68233120
Strand Reverse strand
Band p31.3
Transcripts
ENST00000354777 ENSP00000346829
ENST00000262348 ENSP00000262348
ENST00000370976 ENSP00000360015
ENST00000370973 ENSP00000360012
ENST00000370971 ENSP00000360010
ENST00000498615
ENST00000491811
ENST00000497187
ENST00000471243 ENSP00000436196
ENST00000491076 ENSP00000433188
ENST00000534713 ENSP00000431552
ENST00000533537 ENSP00000433690
ENST00000530486 ENSP00000433111
ENST00000527864 ENSP00000433867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0031852 mu-type opioid receptor binding
Biological Process
GO:0001707 mesoderm formation
GO:0009948 anterior/posterior axis specification
GO:0016055 Wnt signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032590 dendrite membrane
GO:0032839 dendrite cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028173
View Gene Order
ENSBTAG00000012976
Not yet available
Pathways
NETPATH
REACTOME
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_228014
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_111102
Signal Transduction pathway
REACT_163710
WNT ligand biogenesis and trafficking pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001002292 NM_001193334 NM_024911
HUGO
OMIM
CCDS CCDS30750 CCDS53331 CCDS642
HPRD 10980
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca