Version 5.4
Homo sapiens Gene: PTGER3
Summary
InnateDB Gene IDBG-99662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGER3
Gene Name prostaglandin E receptor 3 (subtype EP3)
Synonyms EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2-R
Species Homo sapiens
Ensembl Gene ENSG00000050628
Encoded Proteins
IDBP-99670
prostaglandin E receptor 3 (subtype EP3)
IDBP-481991
prostaglandin E receptor 3 (subtype EP3)
IDBP-99674
prostaglandin E receptor 3 (subtype EP3)
IDBP-99678
prostaglandin E receptor 3 (subtype EP3)
IDBP-99682
prostaglandin E receptor 3 (subtype EP3)
IDBP-99686
prostaglandin E receptor 3 (subtype EP3)
IDBP-99688
prostaglandin E receptor 3 (subtype EP3)
IDBP-99690
prostaglandin E receptor 3 (subtype EP3)
IDBP-482484
prostaglandin E receptor 3 (subtype EP3)
IDBP-484304
prostaglandin E receptor 3 (subtype EP3)
IDBP-482890
prostaglandin E receptor 3 (subtype EP3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:70852353-71047808
Strand Reverse strand
Band p31.1
Transcripts
ENST00000370932 ENSP00000359970
ENST00000361210 ENSP00000424340
ENST00000370931 ENSP00000359969
ENST00000354608 ENSP00000346624
ENST00000356595 ENSP00000349003
ENST00000306666 ENSP00000302313
ENST00000351052 ENSP00000280208
ENST00000370924 ENSP00000359962
ENST00000479353 ENSP00000421583
ENST00000497146 ENSP00000423561
ENST00000460330 ENSP00000418073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004930 G-protein coupled receptor activity
GO:0004957 prostaglandin E receptor activity
GO:0005515 protein binding
Biological Process
GO:0001660 fever generation
GO:0006351 transcription, DNA-templated
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008150 biological_process
GO:0008219 cell death
GO:0015701 bicarbonate transport
GO:0030522 intracellular receptor signaling pathway
GO:0031622 positive regulation of fever generation
GO:0032496 response to lipopolysaccharide
GO:0035810 positive regulation of urine volume
Cellular Component
GO:0005635 nuclear envelope
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040016
View Gene Order
ENSBTAG00000019230
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18425
Prostanoid ligand receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445000 Hs.595760
RefSeq NM_001126044 NM_198714 NM_198715 NM_198716 NM_198717 NM_198718 NM_198719
HUGO
OMIM
CCDS CCDS652 CCDS655 CCDS656 CCDS657 CCDS658
HPRD 08906
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca