Version 5.4
Homo sapiens Gene: FUBP1
Summary
InnateDB Gene IDBG-99850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUBP1
Gene Name far upstream element (FUSE) binding protein 1
Synonyms FBP; FUBP
Species Homo sapiens
Ensembl Gene ENSG00000162613
Encoded Proteins
IDBP-99854
far upstream element (FUSE) binding protein 1
IDBP-99856
far upstream element (FUSE) binding protein 1
IDBP-99858
far upstream element (FUSE) binding protein 1
IDBP-386037
far upstream element (FUSE) binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:77944055-77979110
Strand Reverse strand
Band p31.1
Transcripts
ENST00000294623 ENSP00000294623
ENST00000370768 ENSP00000359804
ENST00000370767 ENSP00000359803
ENST00000421641 ENSP00000402630
ENST00000488814
ENST00000474632
ENST00000492405
ENST00000492724
ENST00000480673
ENST00000483894
ENST00000489495
ENST00000487684
ENST00000470287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
Experimentally validated
Total 70 [view]
Protein-Protein 68 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028034
View Gene Order
ENSBTAG00000008926
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.634693
RefSeq NM_003902 XM_006711022
HUGO
OMIM
CCDS CCDS683
HPRD 10349
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca