Version 5.4
| Homo sapiens Gene: PRKACB | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-99931.6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | PRKACB | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | protein kinase, cAMP-dependent, catalytic, beta | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | PKA C-beta; PKACB | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSG00000142875 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, catalytic, beta
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011] The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 1:84078062-84238498 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | p31.1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Rap1 signalling pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Gluconeogenesis pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
PKA-mediated phosphorylation of key metabolic factors pathway
Integration of energy metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Myoclonic epilepsy of Lafora pathway
Neuronal System pathway
Signaling by VEGF pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Degradation of GLI1 by the proteasome pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Adaptive Immune System pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
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| KEGG |
GnRH signaling pathway pathway
Vibrio cholerae infection pathway
Gap junction pathway
Wnt signaling pathway pathway
Olfactory transduction pathway
Hedgehog signaling pathway pathway
Apoptosis pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Insulin signaling pathway pathway
Taste transduction pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Parkinson's disease pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Prion diseases pathway
Progesterone-mediated oocyte maturation pathway
Dilated cardiomyopathy pathway
Vasopressin-regulated water reabsorption pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Amoebiasis pathway
Salivary secretion pathway
Bile secretion pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
Hedgehog signaling pathway pathway
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| PID NCI |
p75(NTR)-mediated signaling
p73 transcription factor network
Alpha4 beta1 integrin signaling events
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Hs.487325 Hs.692873 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001242857 NM_001242858 NM_001242859 NM_001242860 NM_001242861 NM_001242862 NM_001300915 NM_001300917 NM_002731 NM_182948 NM_207578 XM_005271015 XM_005271016 XM_005271017 XM_005271018 XM_005271019 XM_005271022 XM_005271023 XM_006710758 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS55610 CCDS55611 CCDS691 CCDS692 CCDS693 CCDS72812 CCDS72813 CCDS72814 CCDS72815 CCDS72816 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | 01482 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||