InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP5F1

Summary

InnateDB Protein

IDBP-101066.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5F1

Protein Name

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1

Synonyms

PIG47;

Species

Homo sapiens

Ensembl Protein

ENSP00000358737

InnateDB Gene

IDBG-101064 (ATP5F1)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0021762	substantia nigra development
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome