InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gopc

Summary

InnateDB Protein

IDBP-150970.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gopc

Protein Name

golgi associated PDZ and coiled-coil motif containing

Synonyms

2210402P09Rik; AI844555; CAL; FIG; GOPC1; PIST;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020008

InnateDB Gene

IDBG-150968 (Gopc)

Protein Structure

UniProt Annotation

Function

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. {ECO:0000269PubMed:12149515, ECO:0000269PubMed:12372286, ECO:0000269PubMed:15317815}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans- Golgi network (TGN) of spermatids and the medulla of round spermatides.

Disease Associations

Tissue Specificity

Ubiquitously expressed (at protein level). Expressed in dorsal root glanglion (DRG), spinal chord and brain. Isoform 1 is preferentially expressed in whole brain (at protein level) and cerebellum. Expressed in spermatocytes and spermatides but not in Sertoli cells and spermatogonia. {ECO:0000269PubMed:11384996, ECO:0000269PubMed:12149515, ECO:0000269PubMed:12372286, ECO:0000269PubMed:15317815}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019905	syntaxin binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding

Biological Process

GO:0006914	autophagy
GO:0007289	spermatid nucleus differentiation
GO:0015031	protein transport
GO:0050790	regulation of catalytic activity
GO:0051260	protein homooligomerization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030140	trans-Golgi network transport vesicle
GO:0030425	dendrite
GO:0043234	protein complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane