Version 5.4
Mus musculus Protein: Mfsd7c
Summary
InnateDB Protein IDBP-158654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfsd7c
Protein Name major facilitator superfamily domain containing 7C
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035569
InnateDB Gene IDBG-158652 (Mfsd7c)
Protein Structure
UniProt Annotation
Function Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Found in the kidney and in cells implicated in rapid calcium exchange, namely the CNS, the eye, cardiomyocytes and placenta in late term.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015232 heme transporter activity
GO:0020037 heme binding
Biological Process
GO:0015886 heme transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2384974
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91X85
PhosphoSite PhosphoSite-Q91X85
TrEMBL Q3UL56
UniProt Splice Variant
Entrez Gene 217721
UniGene Mm.417320
RefSeq NP_663422
MGI ID
MGI Symbol Mfsd7c
OMIM
CCDS CCDS26062
HPRD
IMGT
EMBL AK145696 AY260574 AY260575 AY260576 BC011209
GenPept AAH11209 AAP86635 AAP86636 AAP86637 BAE26594

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca