InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcf3

Summary

InnateDB Protein

IDBP-174165.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf3

Protein Name

transcription factor 3

Synonyms

A1; AA408400; ALF2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020379

InnateDB Gene

IDBG-174161 (Tcf3)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. {ECO:0000269PubMed:18214987}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 129 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	119 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	129 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001779	natural killer cell differentiation
GO:0002326	B cell lineage commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007369	gastrulation
GO:0010628	positive regulation of gene expression
GO:0030098	lymphocyte differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0033077	T cell differentiation in thymus
GO:0033152	immunoglobulin V(D)J recombination
GO:0042493	response to drug
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045666	positive regulation of neuron differentiation
GO:0045787	positive regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048541	Peyer's patch development
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:2000045	regulation of G1/S transition of mitotic cell cycle