Version 5.4
| Mus musculus Protein: Gpr132 | |||||
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| Summary | |||||
| InnateDB Protein | IDBP-175230.6 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | Gpr132 | ||||
| Protein Name | G protein-coupled receptor 132 | ||||
| Synonyms | G2a; | ||||
| Species | Mus musculus | ||||
| Ensembl Protein | ENSMUSP00000021729 | ||||
| InnateDB Gene | IDBG-175228 (Gpr132) | ||||
| Protein Structure |
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| UniProt Annotation | |||||
| Function | May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton- sensing activity (By similarity). {ECO:0000250}. | ||||
| Subcellular Localization | Cell membrane {ECO:0000305PubMed:15728718}; Multi-pass membrane protein {ECO:0000305PubMed:15728718}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface. | ||||
| Disease Associations | |||||
| Tissue Specificity | Highly expressed in hematopoietic tissues rich in lymphocytes like spleen and thymus. Weakly expressed in heart and lung. Highly expressed in infiltrating macrophages within atherosclerotic lesions. {ECO:0000269PubMed:12482833}. | ||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||
| PDB ID | MGI:1890220 | ||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR005388 G2A lysophosphatidylcholine receptor IPR017452 GPCR, rhodopsin-like, 7TM |
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| PFAM |
PF00001
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| PRINTS |
PR00237
PR01563 |
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| PIRSF | |||||
| SMART | |||||
| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q9Z282 | ||||
| PhosphoSite | PhosphoSite- | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 56696 | ||||
| UniGene | Mm.20455 | ||||
| RefSeq | NP_064309 | ||||
| MGI ID | |||||
| MGI Symbol | Gpr132 | ||||
| OMIM | |||||
| CCDS | CCDS26199 | ||||
| HPRD | |||||
| IMGT | |||||
| EMBL | AF083442 AK089866 AK153765 BC120522 BC120524 | ||||
| GenPept | AAC67542 AAI20523 AAI20525 BAC40980 BAE32176 | ||||