Bos taurus Protein: APLF
Summary
InnateDB Protein IDBP-178928.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol APLF
Protein Name Aprataxin and PNK-like factor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042099
InnateDB Gene IDBG-12093 (APLF)
Protein Structure
UniProt Annotation
Function Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520 endodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) lyase activity
GO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) lyase activity
Biological Process
GO:0000012 single strand break repair
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR008984 SMAD/FHA domain
IPR019406 Zinc finger, C2H2, APLF-like
PFAM PF10283
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JNH9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507989
UniGene
RefSeq NP_001071342
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126691
GenPept AAI26692