InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkra

Summary

InnateDB Protein

IDBP-182097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkra

Protein Name

protein kinase, interferon inducible double stranded RNA dependent activator

Synonyms

AV120107; lear; Pact; PRK; RAX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002808

InnateDB Gene

IDBG-182095 (Prkra)

Protein Structure

UniProt Annotation

Function

Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. {ECO:0000250, ECO:0000269PubMed:10336432, ECO:0000269PubMed:22214662}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. {ECO:0000269PubMed:10336432}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0030422	production of siRNA involved in RNA interference
GO:0034599	cellular response to oxidative stress
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0048705	skeletal system morphogenesis
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway