InnateDB Protein
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IDBP-182097.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Prkra
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Protein Name
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protein kinase, interferon inducible double stranded RNA dependent activator
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Synonyms
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AV120107; lear; Pact; PRK; RAX;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000002808
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InnateDB Gene
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IDBG-182095 (Prkra)
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Protein Structure
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Function |
Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. {ECO:0000250, ECO:0000269PubMed:10336432, ECO:0000269PubMed:22214662}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, muscle, spleen and testis. {ECO:0000269PubMed:10336432}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
31 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1344375
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InterPro |
IPR014720
Double-stranded RNA-binding domain
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PFAM |
PF00035
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PRINTS |
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PIRSF |
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SMART |
SM00358
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WTX2
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PhosphoSite |
PhosphoSite-Q9WTX2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23992
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UniGene |
Mm.277250
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RefSeq |
NP_036001
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MGI ID |
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MGI Symbol |
Prkra
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OMIM |
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CCDS |
CCDS16159
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HPRD |
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IMGT |
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EMBL |
AF083032
AK012798
AK155112
BC011311
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GenPept |
AAD33098
AAH11311
BAB28477
BAE33056
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