InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nqo1

Summary

InnateDB Protein

IDBP-190810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nqo1

Protein Name

NAD(P)H dehydrogenase, quinone 1

Synonyms

AV001255; Dia4; Dtd; Nmo-1; Nmo1; Nmor1; Ox-1; Ox1; Qr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003947

InnateDB Gene

IDBG-190808 (Nqo1)

Protein Structure

UniProt Annotation

Function

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003955	NAD(P)H dehydrogenase (quinone) activity
GO:0004784	superoxide dismutase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0007584	response to nutrient
GO:0014070	response to organic cyclic compound
GO:0019430	removal of superoxide radicals
GO:0032355	response to estradiol
GO:0043086	negative regulation of catalytic activity
GO:0043525	positive regulation of neuron apoptotic process
GO:0045471	response to ethanol
GO:0055114	oxidation-reduction process