InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aacs

Summary

InnateDB Protein

IDBP-201422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aacs

Protein Name

acetoacetyl-CoA synthetase

Synonyms

2210408B16Rik; SUR5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031445

InnateDB Gene

IDBG-201420 (Aacs)

Protein Structure

UniProt Annotation

Function

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0030729	acetoacetate-CoA ligase activity
GO:0047760	butyrate-CoA ligase activity

Biological Process

GO:0001889	liver development
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0014074	response to purine-containing compound
GO:0032024	positive regulation of insulin secretion
GO:0034201	response to oleic acid
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0045471	response to ethanol
GO:0050872	white fat cell differentiation
GO:0060612	adipose tissue development
GO:0071333	cellular response to glucose stimulus
GO:0071394	cellular response to testosterone stimulus
GO:0071397	cellular response to cholesterol