InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lin9

Summary

InnateDB Protein

IDBP-207226.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lin9

Protein Name

lin-9 homolog (C. elegans)

Synonyms

2700022J23Rik; Bara; Lin-9; mLin-9; TGS; TGS1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082959

InnateDB Gene

IDBG-207222 (Lin9)

Protein Structure

UniProt Annotation

Function

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Note=Found in perinucleolar structures. Associated with chromatin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle

Cellular Component

GO:0005654	nucleoplasm
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

MGI:1919818

InterPro

IPR010561 Protein LIN-9/Protein ALWAYS EARLY

PFAM

PF06584

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C735

PhosphoSite

PhosphoSite-Q8C735

TrEMBL

UniProt Splice Variant

Entrez Gene

72568

UniGene

Mm.275044

RefSeq

NP_001096652

MGI ID

MGI Symbol

Lin9

OMIM

CCDS

CCDS48468

HPRD

IMGT

EMBL

AF190325 AK042357 AK052618

GenPept

AAQ13712 BAC31235 BAC35065