Version 5.4
Mus musculus Protein: Chmp6
Summary
InnateDB Protein IDBP-214731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chmp6
Protein Name charged multivesicular body protein 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000026434
InnateDB Gene IDBG-214729 (Chmp6)
Protein Structure
UniProt Annotation
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity). {ECO:0000250}.
Subcellular Localization Endomembrane system {ECO:0000250}. Endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Late endosome membrane {ECO:0000250}. Note=Localizes to endosomal membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:3583942
InterPro IPR005024 Snf7
PFAM PF03357
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0C0A3
PhosphoSite PhosphoSite-P0C0A3
TrEMBL Q3TS10
UniProt Splice Variant
Entrez Gene 208092
UniGene
RefSeq NP_001078967
MGI ID
MGI Symbol Chmp6
OMIM
CCDS CCDS36385
HPRD
IMGT
EMBL AK162346 AL929234 BC147754 BC147755 BI157958 CH466558
GenPept AAI47755 AAI47756 BAE36866 EDL34718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca