InnateDB Protein
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IDBP-236644.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EAF1
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Protein Name
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ELL associated factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380054
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InnateDB Gene
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IDBG-20761 (EAF1)
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Protein Structure
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Function |
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. {ECO:0000269PubMed:11418481, ECO:0000269PubMed:16006523}.
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Subcellular Localization |
Nucleus speckle. Nucleus, Cajal body. Note=Colocalizes with ELL to nuclear speckles. Also localized to Cajal (coiled) bodies.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. {ECO:0000269PubMed:11418481}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019194
Transcription elognation factor Eaf, N-terminal
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PFAM |
PF09816
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JC9
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PhosphoSite |
PhosphoSite-Q96JC9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
85403
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UniGene |
Hs.716733
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RefSeq |
NP_149074
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HUGO |
HGNC:20907
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OMIM |
608315
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CCDS |
CCDS2626
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HPRD |
12209
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IMGT |
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EMBL |
AF272973
BC041329
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GenPept |
AAH41329
AAK58687
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