Version 5.4
Homo sapiens Protein: WRAP53
Summary
InnateDB Protein IDBP-237447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WRAP53
Protein Name WD repeat containing, antisense to TP53
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379727
InnateDB Gene IDBG-26580 (WRAP53)
Protein Structure
UniProt Annotation
Function Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post- transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage. {ECO:0000269PubMed:19179534, ECO:0000269PubMed:19250907}.
Subcellular Localization Nucleus, Cajal body. Cytoplasm.
Disease Associations Dyskeratosis congenita, autosomal recessive, 3 (DKCB3) [MIM:613988]: A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. {ECO:0000269PubMed:21205863}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in all tissues and cell lines examined. {ECO:0000269PubMed:19250907}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0032203 telomere formation via telomerase
GO:0051973 positive regulation of telomerase activity
Cellular Component
GO:0005634 nucleus
GO:0005697 telomerase holoenzyme complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BUR4
PhosphoSite PhosphoSite-Q9BUR4
TrEMBL C6ZGR0
UniProt Splice Variant
Entrez Gene 55135
UniGene Hs.735124
RefSeq NP_060551
HUGO HGNC:25522
OMIM 612661
CCDS CCDS11119
HPRD 07670
IMGT
EMBL AK001247 AK056669 AY766322 BC002336 CH471108 DQ431240 DQ431241 EU876947 EU876948 EU876949 EU876953 EU876955 EU876957 EU876958 EU876959 EU876961 EU876962 EU876963 EU876964 EU876965 EU876966 EU876967 EU876968 EU876969 EU876970 EU876971 EU876973 EU876974 EU876975 EU876976 EU876977 EU876978 EU876979 EU876980 EU876981 EU876982 EU876983 EU876985 EU876986 EU876987 EU876988 EU876989 EU876992 EU876993 EU876994 EU876995 EU876996 EU876997 EU876998 EU876999 EU877000 EU877001 EU877002 EU877003 EU877004 EU877005 EU877006 EU877008 EU877010 EU877011 EU877012 EU877013 EU877014 EU877015 EU877017 EU877018 EU877019 EU877021 EU877023 EU877027 EU877028 EU877031 EU877033 EU877042 EU877046 EU877051 EU877053
GenPept AAH02336 AAW92115 ABD92817 ABD92818 ACM07586 ACM07587 ACM07588 ACM07592 ACM07594 ACM07596 ACM07597 ACM07598 ACM07600 ACM07601 ACM07602 ACM07603 ACM07604 ACM07605 ACM07606 ACM07607 ACM07608 ACM07609 ACM07610 ACM07612 ACM07613 ACM07614 ACM07615 ACM07616 ACM07617 ACM07618 ACM07619 ACM07620 ACM07621 ACM07622 ACM07624 ACM07625 ACM07626 ACM07627 ACM07628 ACM07631 ACM07632 ACM07633 ACM07634 ACM07635 ACM07636 ACM07637 ACM07638 ACM07639 ACM07640 ACM07641 ACM07642 ACM07643 ACM07644 ACM07645 ACM07647 ACM07649 ACM07650 ACM07651 ACM07652 ACM07653 ACM07654 ACM07656 ACM07657 ACM07658 ACM07660 ACM07662 ACM07666 ACM07667 ACM07670 ACM07672 ACM07681 ACM07685 ACM07690 ACM07692 BAA91579 BAG51781 EAW90136 EAW90138 EAW90139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca