InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CELF1

Summary

InnateDB Protein

IDBP-239849.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELF1

Protein Name

CUGBP, Elav-like family member 1

Synonyms

BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR;

Species

Homo sapiens

Ensembl Protein

ENSP00000378706

InnateDB Gene

IDBG-43515 (CELF1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. {ECO:0000250, ECO:0000269PubMed:10536163, ECO:0000269PubMed:11124939, ECO:0000269PubMed:11158314, ECO:0000269PubMed:12649496, ECO:0000269PubMed:12799066, ECO:0000269PubMed:14726956, ECO:0000269PubMed:16601207, ECO:0000269PubMed:16946708}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:8948631}. Cytoplasm {ECO:0000269PubMed:8948631}. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10893231, ECO:0000269PubMed:11158314, ECO:0000269PubMed:16862542}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0042835	BRE binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006376	mRNA splice site selection
GO:0006397	mRNA processing
GO:0007281	germ cell development
GO:0009790	embryo development
GO:0016246	RNA interference
GO:0017148	negative regulation of translation
GO:0043484	regulation of RNA splicing